Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 2975358..2975887 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag MR176_RS13805 Protein ID WP_003417760.1
Coordinates 2975358..2975615 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag MR176_RS13810 Protein ID WP_003417757.1
Coordinates 2975612..2975887 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS13775 2971787..2972179 + 393 WP_003417776.1 serine protease inhibitor -
MR176_RS13780 2972157..2972525 + 369 WP_003417772.1 DUF742 domain-containing protein -
MR176_RS13785 2972506..2973087 + 582 WP_003417769.1 ATP/GTP-binding protein -
MR176_RS13790 2973094..2973645 + 552 WP_003417767.1 pentapeptide repeat protein MfpA -
MR176_RS13795 2973642..2974009 - 368 Protein_2727 FHA domain-containing protein -
MR176_RS13800 2974126..2975316 - 1191 WP_003900033.1 NADH:flavin oxidoreductase -
MR176_RS13805 2975358..2975615 - 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
MR176_RS13810 2975612..2975887 - 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
MR176_RS13815 2976011..2976856 + 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
MR176_RS13820 2976853..2977146 + 294 WP_003417749.1 DUF3017 domain-containing protein -
MR176_RS13825 2977160..2977549 - 390 WP_003417745.1 DUF732 domain-containing protein -
MR176_RS13830 2977664..2977924 + 261 WP_003417741.1 hypothetical protein -
MR176_RS13835 2977951..2978438 + 488 Protein_2735 FAD-binding protein -
MR176_RS13840 2978625..2979314 + 690 WP_234715169.1 BBE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T295241 WP_003417760.1 NZ_OW052302:c2975615-2975358 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT295241 WP_003417757.1 NZ_OW052302:c2975887-2975612 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References