Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 2948182..2948849 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MR176_RS13680 Protein ID WP_016719661.1
Coordinates 2948457..2948849 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag MR176_RS13675 Protein ID WP_003912214.1
Coordinates 2948182..2948457 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS13660 2943301..2944173 + 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -
MR176_RS13665 2944244..2946439 - 2196 WP_010886168.1 PE family protein -
MR176_RS13670 2946629..2948000 - 1372 Protein_2702 ISNCY family transposase -
MR176_RS13675 2948182..2948457 + 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR176_RS13680 2948457..2948849 + 393 WP_016719661.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS13685 2949603..2950655 + 1053 WP_003900678.1 polyprenyl synthetase family protein -
MR176_RS13690 2950655..2951644 + 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MR176_RS13695 2951641..2953479 + 1839 WP_003918607.1 1-deoxy-D-xylulose-5-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2946629..2947306 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14346.77 Da        Isoelectric Point: 10.7249

>T295240 WP_016719661.1 NZ_OW052302:2948457-2948849 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARTEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT295240 WP_003912214.1 NZ_OW052302:2948182-2948457 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References