Detailed information of TA system TA029524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): spoIISABC/SpoIISA-SpoIISB
• Location: 1462917..1463836
• Replicon: chromosome
• Accession: NC_021362
• Organism: Bacillus licheniformis 9945A

Toxin (Protein)

• Gene name: spoIISA
• Uniprot ID: -
• Locus tag: BALI_RS07350
• Protein ID: WP_020451047.1
• Coordinates: 1463090..1463836 (-)
• Length: 249 a.a.

Antitoxin (Protein)

• Gene name: spoIISB
• Uniprot ID: -
• Locus tag: BALI_RS07345
• Protein ID: WP_020451046.1
• Coordinates: 1462917..1463090 (-)
• Length: 58 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BALI_RS07325	1458336..1459433	+	1098	WP_020451042.1	mannonate dehydratase	-
BALI_RS07330	1459409..1460257	+	849	WP_020451043.1	SDR family oxidoreductase	-
BALI_RS07335	1460285..1461298	+	1014	WP_020451044.1	zinc-binding alcohol dehydrogenase family protein	-
BALI_RS07340	1461350..1462621	+	1272	WP_020451045.1	MFS transporter	-
BALI_RS07345	1462917..1463090	-	174	WP_020451046.1	type II toxin-antitoxin system SpoIISB family antitoxin	Antitoxin
BALI_RS07350	1463090..1463836	-	747	WP_020451047.1	type II toxin-antitoxin system SpoIISA family toxin	Toxin
BALI_RS07355	1463946..1464944	-	999	WP_020451048.1	inorganic phosphate transporter	-
BALI_RS07360	1464957..1465574	-	618	WP_020451049.1	DUF47 domain-containing protein	-
BALI_RS07365	1465906..1467663	+	1758	WP_020451051.1	gamma-glutamyltransferase	-
BALI_RS07370	1467800..1468444	+	645	WP_020451052.1	YesL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SpoIISA, type II toxin-antitoxin system (3-238)

Antitoxin

• Antitoxin SpoIISB (1-57)

Sequences

Toxin

Protein

• Length: 249 a.a.
• Molecular weight: 29435.89 Da
• Isoelectric Point: 4.6065

>T29524 WP_020451047.1 NC_021362:c1463836-1463090 [Bacillus paralicheniformis ATCC 9945a]
MLLFYQFLVWLIVLALALYVAAVWRFEKKLTEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLERKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEEGDD

Nucleotide

• Length: 747 bp

>T29524 NC_021362:c1463836-1463090 [Bacillus paralicheniformis ATCC 9945a]
ATGCTGCTATTTTATCAATTCCTTGTTTGGCTCATTGTTTTGGCGCTGGCTCTGTATGTAGCTGCCGTGTGGCGTTTTGA
AAAAAAGCTCACCGAAAAAACGGTCGCGATCCGAAAAACGTGGTACCTGCTTTATGTTATCGGCGCCGTGATTTATTGGA
CGCACGATCCGCAGTCGATTTTCACAAACCCGCTTCATTACTTGATCGTTGCCGTTTTTTTCACGCTGACAGACGCTTTT
ATTTTCTTAAACGCCTACTTTAAAAAGCTCGGCAGCTCCGAACTCGCGACAGACACAAGAATGCTTCTCGAAGAAAACAA
CGACCTCCTCCACACATATCAAAACAGGCTGAAAACGTTTCAATACCTATTGAAAAACGAACCGATCCACATCTATTATG
GAAATATAGAAGCGTATGCAGAAGGGATCGAAAAGCTCATCAAACGGTTTGCCGAAAAAATGAATATATCCGCTGCACTT
TGCGAATATAATTCAGAAGAAAGCAAGGATCATTTGCTTGAGCATATGGAAAACCGGTTCGATGTTCAAGAAAAGCTTGA
GCGCAAAGACGTTTATTATGAAGAAAACGGAAAAATGGTCCTCATTCCTTTTTCCATCCACGATTTTGACTATGTCATGA
AGTTAACCTCAGAAGACCTTGTCACAGAATTTGACTACCTCCTGTTTACTTCTTTAACAAGCATCTATGATCTTCTGCTA
CCAAACGAAGAGGAAGGTGACGACTGA

Antitoxin

Protein

• Length: 58 a.a.
• Molecular weight: 6926.00 Da
• Isoelectric Point: 10.9186

>AT29524 WP_020451046.1 NC_021362:c1463090-1462917 [Bacillus paralicheniformis ATCC 9945a]
MEPAFQQDHESAKKRLAFKMFKRQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Nucleotide

• Length: 174 bp

>AT29524 NC_021362:c1463090-1462917 [Bacillus paralicheniformis ATCC 9945a]
ATGGAGCCTGCTTTTCAGCAAGACCATGAAAGCGCAAAAAAGCGCCTCGCCTTTAAAATGTTTAAAAGGCAATCCAAAAC
CAATATCGCGAAATACGAAGTCAGCCCCCATACCGAACGGATTTTCCGGCAAAACGAACGGCTGATCGGCGAGTATAAAA
GAAAAAAAGCTTAA