Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2920959..2921644 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag MR176_RS13555 Protein ID WP_003417998.1
Coordinates 2920959..2921369 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MR176_RS13560 Protein ID WP_003912220.1
Coordinates 2921366..2921644 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS13540 2916398..2917987 + 1590 WP_003900682.1 IMP dehydrogenase -
MR176_RS13545 2918007..2919134 + 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
MR176_RS13550 2919190..2920926 + 1737 WP_003418002.1 cholesterol oxidase -
MR176_RS13555 2920959..2921369 - 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS13560 2921366..2921644 - 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR176_RS13565 2921700..2922587 - 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
MR176_RS13570 2922649..2923215 + 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
MR176_RS13575 2923333..2924037 + 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
MR176_RS13580 2924054..2925655 + 1602 WP_003417969.1 FAD/NAD(P)-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T295239 WP_003417998.1 NZ_OW052302:c2921369-2920959 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT295239 WP_003912220.1 NZ_OW052302:c2921644-2921366 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References