Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2262917..2263550 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag MR176_RS10505 Protein ID WP_003400580.1
Coordinates 2262917..2263318 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag MR176_RS10510 Protein ID WP_003400577.1
Coordinates 2263311..2263550 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS10490 2258927..2259838 - 912 WP_003899798.1 SDR family NAD(P)-dependent oxidoreductase -
MR176_RS10495 2259941..2260510 + 570 WP_003400591.1 TetR/AcrR family transcriptional regulator -
MR176_RS10500 2260628..2262865 + 2238 WP_015629335.1 NADP-dependent isocitrate dehydrogenase -
MR176_RS10505 2262917..2263318 - 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
MR176_RS10510 2263311..2263550 - 240 WP_003400577.1 antitoxin VapB1 Antitoxin
MR176_RS10515 2263617..2266556 - 2940 WP_003901785.1 UPF0182 family protein -
MR176_RS10520 2266597..2266758 - 162 WP_003899796.1 hypothetical protein -
MR176_RS10525 2266814..2268253 - 1440 WP_003901784.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T295238 WP_003400580.1 NZ_OW052302:c2263318-2262917 [Mycobacterium tuberculosis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT295238 WP_003400577.1 NZ_OW052302:c2263550-2263311 [Mycobacterium tuberculosis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHM7

References