Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1967588..1968231 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag MR176_RS09265 Protein ID WP_003401566.1
Coordinates 1967588..1968013 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag MR176_RS09270 Protein ID WP_003401563.1
Coordinates 1968010..1968231 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS09255 1965916..1966824 - 909 WP_003900117.1 protochlorophyllide reductase -
MR176_RS09260 1966821..1967453 - 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
MR176_RS09265 1967588..1968013 - 426 WP_003401566.1 PIN domain nuclease Toxin
MR176_RS09270 1968010..1968231 - 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
MR176_RS09275 1968279..1968581 - 303 WP_015629470.1 toxin-antitoxin system toxin -
MR176_RS09280 1968578..1968805 - 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
MR176_RS09285 1968948..1970723 - 1776 WP_010886074.1 PE family protein -
MR176_RS09290 1970902..1972299 + 1398 WP_003401544.1 sulfatase -
MR176_RS09295 1972309..1973112 + 804 WP_003401540.1 Stf0 family sulphotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T295235 WP_003401566.1 NZ_OW052302:c1968013-1967588 [Mycobacterium tuberculosis]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT295235 WP_003401563.1 NZ_OW052302:c1968231-1968010 [Mycobacterium tuberculosis]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
PDB 3H87
AlphaFold DB A0A829CG48

References