Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 1886813..1887824 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MR176_RS08940 Protein ID WP_003401859.1
Coordinates 1887231..1887824 (+) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MR176_RS08935 Protein ID WP_003401860.1
Coordinates 1886813..1887202 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS08910 1882661..1883416 + 756 WP_003401865.1 XdhC family protein -
MR176_RS08915 1883413..1884006 + 594 WP_003401864.1 NTP transferase domain-containing protein -
MR176_RS08920 1884003..1884899 + 897 WP_242342099.1 MoxR family ATPase -
MR176_RS08925 1884913..1885515 + 603 WP_003898417.1 SRPBCC family protein -
MR176_RS08930 1885521..1886732 + 1212 WP_003401861.1 VWA domain-containing protein -
MR176_RS08935 1886813..1887202 + 390 WP_003401860.1 hypothetical protein Antitoxin
MR176_RS08940 1887231..1887824 + 594 WP_003401859.1 zeta toxin family protein Toxin
MR176_RS08945 1887849..1888979 + 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
MR176_RS08950 1888968..1889651 - 684 WP_003401857.1 VTT domain-containing protein -
MR176_RS08955 1889747..1890781 + 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MR176_RS08960 1890793..1892175 - 1383 WP_003898415.1 magnesium transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T295234 WP_003401859.1 NZ_OW052302:1887231-1887824 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT295234 WP_003401860.1 NZ_OW052302:1886813-1887202 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References