Detailed information of TA system TA295234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 1886813..1887824
• Replicon: chromosome
• Accession: NZ_OW052302
• Organism: Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: L7N5R2
• Locus tag: MR176_RS08940
• Protein ID: WP_003401859.1
• Coordinates: 1887231..1887824 (+)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: O53702
• Locus tag: MR176_RS08935
• Protein ID: WP_003401860.1
• Coordinates: 1886813..1887202 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MR176_RS08910	1882661..1883416	+	756	WP_003401865.1	XdhC family protein	-
MR176_RS08915	1883413..1884006	+	594	WP_003401864.1	NTP transferase domain-containing protein	-
MR176_RS08920	1884003..1884899	+	897	WP_242342099.1	MoxR family ATPase	-
MR176_RS08925	1884913..1885515	+	603	WP_003898417.1	SRPBCC family protein	-
MR176_RS08930	1885521..1886732	+	1212	WP_003401861.1	VWA domain-containing protein	-
MR176_RS08935	1886813..1887202	+	390	WP_003401860.1	hypothetical protein	Antitoxin
MR176_RS08940	1887231..1887824	+	594	WP_003401859.1	zeta toxin family protein	Toxin
MR176_RS08945	1887849..1888979	+	1131	WP_003401858.1	glycoside hydrolase family 76 protein	-
MR176_RS08950	1888968..1889651	-	684	WP_003401857.1	VTT domain-containing protein	-
MR176_RS08955	1889747..1890781	+	1035	WP_003401856.1	class II fructose-bisphosphate aldolase	-
MR176_RS08960	1890793..1892175	-	1383	WP_003898415.1	magnesium transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 21344.53 Da
• Isoelectric Point: 10.5018

>T295234 WP_003401859.1 NZ_OW052302:1887231-1887824 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Nucleotide

• Length: 594 bp

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13648.21 Da
• Isoelectric Point: 6.0829

>AT295234 WP_003401860.1 NZ_OW052302:1886813-1887202 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Nucleotide

• Length: 390 bp

Structures

Toxin

• AlphaFold DB: A0A7U4BRU8

Antitoxin

• AlphaFold DB: A0A7U4BRT0