Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 1689842..1690518 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag MR176_RS07975 Protein ID WP_003898500.1
Coordinates 1690105..1690518 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag MR176_RS07970 Protein ID WP_003402915.1
Coordinates 1689842..1690108 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS07955 1685276..1686256 - 981 WP_003402923.1 o-succinylbenzoate synthase -
MR176_RS07960 1686253..1687857 - 1605 WP_003402920.1 amidohydrolase -
MR176_RS07965 1687935..1689650 + 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
MR176_RS07970 1689842..1690108 + 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MR176_RS07975 1690105..1690518 + 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS07980 1690832..1691734 + 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
MR176_RS07985 1691830..1692714 + 885 WP_003402909.1 SDR family oxidoreductase -
MR176_RS07990 1692777..1693163 + 387 WP_003402907.1 VOC family protein -
MR176_RS07995 1693283..1694536 + 1254 WP_003402904.1 inorganic phosphate transporter -
MR176_RS08000 1694533..1694811 + 279 WP_003402901.1 hypothetical protein -
MR176_RS08005 1694871..1695173 + 303 WP_003402896.1 DUF3349 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T295233 WP_003898500.1 NZ_OW052302:1690105-1690518 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT295233 WP_003402915.1 NZ_OW052302:1689842-1690108 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References