Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1652417..1653036 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag MR176_RS07805 Protein ID WP_003403047.1
Coordinates 1652417..1652824 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag MR176_RS07810 Protein ID WP_003403039.1
Coordinates 1652821..1653036 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS07795 1648884..1651517 - 2634 WP_003403055.1 GH92 family glycosyl hydrolase -
MR176_RS07800 1651671..1652357 + 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
MR176_RS07805 1652417..1652824 - 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
MR176_RS07810 1652821..1653036 - 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
MR176_RS07815 1653130..1653621 + 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
MR176_RS07820 1653750..1654508 - 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T295232 WP_003403047.1 NZ_OW052302:c1652824-1652417 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT295232 WP_003403039.1 NZ_OW052302:c1653036-1652821 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References