Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 579248..579884 | Replicon | chromosome |
Accession | NC_021362 | ||
Organism | Bacillus licheniformis 9945A |
Toxin (Protein)
Gene name | mazF | Uniprot ID | M5P3Q9 |
Locus tag | BALI_RS02835 | Protein ID | WP_003179128.1 |
Coordinates | 579534..579884 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | M5PDU2 |
Locus tag | BALI_RS02830 | Protein ID | WP_006638778.1 |
Coordinates | 579248..579529 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BALI_RS02810 | 574358..575842 | + | 1485 | WP_041817155.1 | PH domain-containing protein | - |
BALI_RS02815 | 575839..576438 | - | 600 | WP_020450255.1 | rhomboid family intramembrane serine protease | - |
BALI_RS02820 | 576782..577741 | + | 960 | WP_165395380.1 | outer membrane lipoprotein carrier protein LolA | - |
BALI_RS02825 | 577967..579136 | + | 1170 | WP_041817156.1 | alanine racemase | - |
BALI_RS02830 | 579248..579529 | + | 282 | WP_006638778.1 | hypothetical protein | Antitoxin |
BALI_RS02835 | 579534..579884 | + | 351 | WP_003179128.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
BALI_RS02840 | 580002..580829 | + | 828 | WP_020450258.1 | RsbT co-antagonist protein RsbRA | - |
BALI_RS02845 | 580833..581198 | + | 366 | WP_020450259.1 | STAS domain-containing protein | - |
BALI_RS02850 | 581201..581602 | + | 402 | WP_020450260.1 | anti-sigma regulatory factor | - |
BALI_RS02855 | 581613..582620 | + | 1008 | WP_020450261.1 | PP2C family protein-serine/threonine phosphatase | - |
BALI_RS02860 | 582679..583005 | + | 327 | WP_020450262.1 | anti-sigma factor antagonist | - |
BALI_RS02865 | 583005..583487 | + | 483 | WP_020450263.1 | anti-sigma B factor RsbW | - |
BALI_RS02870 | 583453..584244 | + | 792 | WP_023857858.1 | RNA polymerase sigma factor SigB | - |
BALI_RS02875 | 584241..584840 | + | 600 | WP_020450265.1 | SpoIIE family protein phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12990.03 Da Isoelectric Point: 5.7234
>T29523 WP_003179128.1 NC_021362:579534-579884 [Bacillus paralicheniformis ATCC 9945a]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF
Download Length: 351 bp
>T29523 NC_021362:579534-579884 [Bacillus paralicheniformis ATCC 9945a]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10649.03 Da Isoelectric Point: 4.6920
>AT29523 WP_006638778.1 NC_021362:579248-579529 [Bacillus paralicheniformis ATCC 9945a]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG
Download Length: 282 bp
>AT29523 NC_021362:579248-579529 [Bacillus paralicheniformis ATCC 9945a]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGCGAGCGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATTAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGCGAGCGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATTAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6I7FHI4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | M5PDU2 |