Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 579248..579884 Replicon chromosome
Accession NC_021362
Organism Bacillus licheniformis 9945A

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag BALI_RS02835 Protein ID WP_003179128.1
Coordinates 579534..579884 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag BALI_RS02830 Protein ID WP_006638778.1
Coordinates 579248..579529 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BALI_RS02810 574358..575842 + 1485 WP_041817155.1 PH domain-containing protein -
BALI_RS02815 575839..576438 - 600 WP_020450255.1 rhomboid family intramembrane serine protease -
BALI_RS02820 576782..577741 + 960 WP_165395380.1 outer membrane lipoprotein carrier protein LolA -
BALI_RS02825 577967..579136 + 1170 WP_041817156.1 alanine racemase -
BALI_RS02830 579248..579529 + 282 WP_006638778.1 hypothetical protein Antitoxin
BALI_RS02835 579534..579884 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BALI_RS02840 580002..580829 + 828 WP_020450258.1 RsbT co-antagonist protein RsbRA -
BALI_RS02845 580833..581198 + 366 WP_020450259.1 STAS domain-containing protein -
BALI_RS02850 581201..581602 + 402 WP_020450260.1 anti-sigma regulatory factor -
BALI_RS02855 581613..582620 + 1008 WP_020450261.1 PP2C family protein-serine/threonine phosphatase -
BALI_RS02860 582679..583005 + 327 WP_020450262.1 anti-sigma factor antagonist -
BALI_RS02865 583005..583487 + 483 WP_020450263.1 anti-sigma B factor RsbW -
BALI_RS02870 583453..584244 + 792 WP_023857858.1 RNA polymerase sigma factor SigB -
BALI_RS02875 584241..584840 + 600 WP_020450265.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T29523 WP_003179128.1 NC_021362:579534-579884 [Bacillus paralicheniformis ATCC 9945a]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T29523 NC_021362:579534-579884 [Bacillus paralicheniformis ATCC 9945a]
TTGATTGTTAAACGCGGCGATGTTTATTTTGCTGACCTATCTCCTGTTGTTGGCTCAGAACAAGGCGGGGTGCGCCCGGT
TTTAGTGATTCAAAACAACATCGGCAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CAAAATTACCTACCCACGTCGAAATTGATGCGAAACGCTACGGTTTTGAAAGAGATTCCGTTATATTGCTCGAACAAATT
CGGACGATTGACAAGCAAAGATTAACGGACAAAATCACCCATCTCGATGATGAAATGATGGAAAAGGTCAACGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT29523 WP_006638778.1 NC_021362:579248-579529 [Bacillus paralicheniformis ATCC 9945a]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT29523 NC_021362:579248-579529 [Bacillus paralicheniformis ATCC 9945a]
TTGTCTGAATCCAGCGCAACAACTGAAATATTGATTCGCTTGCCAGAAGCTTTAGTATCAGAACTGGATGGTGTCGTCAT
GCAAGATAACGGGAGCAGAAATGAACTGATTTACCAAGCCACAAAAATGTATTTGCGCGAGCGCAAAAATCGACAAATTC
GGGAATCGATGAGACGCGGTTATATGGAGATGGCCAAGATTAATTTGAACATCTCTTCTGAGGCTCAATTTGCAGAGTAT
GAGGCTGAAAACACAGTAGAGCGCTTAGTAAGCGGAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References