Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC(toxin) |
Location | 1626857..1627500 | Replicon | chromosome |
Accession | NZ_OW052302 | ||
Organism | Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P67239 |
Locus tag | MR176_RS07670 | Protein ID | WP_003403187.1 |
Coordinates | 1626857..1627258 (-) | Length | 134 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TQ91 |
Locus tag | MR176_RS07675 | Protein ID | WP_003403184.1 |
Coordinates | 1627255..1627500 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MR176_RS07645 | 1623815..1624420 | - | 606 | WP_003898526.1 | hypothetical protein | - |
MR176_RS07650 | 1624562..1624783 | + | 222 | WP_003898525.1 | DUF4926 domain-containing protein | - |
MR176_RS07655 | 1624835..1625992 | + | 1158 | WP_003898524.1 | hypothetical protein | - |
MR176_RS07660 | 1626072..1626269 | + | 198 | WP_003403191.1 | hypothetical protein | - |
MR176_RS07665 | 1626687..1626866 | - | 180 | Protein_1512 | hypothetical protein | - |
MR176_RS07670 | 1626857..1627258 | - | 402 | WP_003403187.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
MR176_RS07675 | 1627255..1627500 | - | 246 | WP_003403184.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
MR176_RS07680 | 1627545..1628015 | - | 471 | WP_003898523.1 | hypothetical protein | - |
MR176_RS07685 | 1628018..1628728 | - | 711 | Protein_1516 | IS607 family element RNA-guided endonuclease TnpB | - |
MR176_RS07690 | 1628730..1629314 | - | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
MR176_RS07695 | 1629555..1630505 | - | 951 | WP_003900184.1 | DUF1259 domain-containing protein | - |
MR176_RS07700 | 1630577..1630888 | - | 312 | WP_003403164.1 | hypothetical protein | - |
MR176_RS07705 | 1631011..1631706 | + | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
MR176_RS07710 | 1631690..1632220 | + | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 134 a.a. Molecular weight: 14501.21 Da Isoelectric Point: 4.4463
>T295229 WP_003403187.1 NZ_OW052302:c1627258-1626857 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR
Download Length: 402 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSD6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ91 |