Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1619337..1619962 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MR176_RS07620 Protein ID WP_003403218.1
Coordinates 1619337..1619738 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MR176_RS07625 Protein ID WP_003403213.1
Coordinates 1619735..1619962 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS07595 1614427..1615374 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR176_RS07600 1615478..1616542 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MR176_RS07605 1616937..1618028 - 1092 WP_003900977.1 galactokinase -
MR176_RS07610 1618025..1619106 - 1082 Protein_1501 galactose-1-phosphate uridylyltransferase -
MR176_RS07615 1619125..1619208 - 84 Protein_1502 galactose-1-phosphate uridylyltransferase -
MR176_RS07620 1619337..1619738 - 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MR176_RS07625 1619735..1619962 - 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MR176_RS07630 1620157..1620399 - 243 WP_003403210.1 hypothetical protein -
MR176_RS07635 1620396..1621145 - 750 WP_003898528.1 hypothetical protein -
MR176_RS07640 1621229..1623796 + 2568 WP_031651119.1 SEC-C metal-binding domain-containing protein -
MR176_RS07645 1623815..1624420 - 606 WP_003898526.1 hypothetical protein -
MR176_RS07650 1624562..1624783 + 222 WP_003898525.1 DUF4926 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T295228 WP_003403218.1 NZ_OW052302:c1619738-1619337 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT295228 WP_003403213.1 NZ_OW052302:c1619962-1619735 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References