Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1613685..1614334 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag MR176_RS07585 Protein ID WP_003403236.1
Coordinates 1613685..1614080 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag MR176_RS07590 Protein ID WP_003403235.1
Coordinates 1614080..1614334 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS07560 1609012..1610739 + 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -
MR176_RS07565 1610832..1611983 + 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MR176_RS07570 1612055..1612462 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
MR176_RS07575 1612459..1612719 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR176_RS07580 1612851..1613591 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
MR176_RS07585 1613685..1614080 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
MR176_RS07590 1614080..1614334 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
MR176_RS07595 1614427..1615374 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR176_RS07600 1615478..1616542 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MR176_RS07605 1616937..1618028 - 1092 WP_003900977.1 galactokinase -
MR176_RS07610 1618025..1619106 - 1082 Protein_1501 galactose-1-phosphate uridylyltransferase -
MR176_RS07615 1619125..1619208 - 84 Protein_1502 galactose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T295227 WP_003403236.1 NZ_OW052302:c1614080-1613685 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT295227 WP_003403235.1 NZ_OW052302:c1614334-1614080 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References