Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 1612055..1612719 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P96917
Locus tag MR176_RS07570 Protein ID WP_003403246.1
Coordinates 1612055..1612462 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF18
Locus tag MR176_RS07575 Protein ID WP_003403244.1
Coordinates 1612459..1612719 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS07560 1609012..1610739 + 1728 WP_003900979.1 exodeoxyribonuclease V subunit alpha -
MR176_RS07565 1610832..1611983 + 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MR176_RS07570 1612055..1612462 - 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS07575 1612459..1612719 - 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR176_RS07580 1612851..1613591 + 741 WP_003403239.1 TVP38/TMEM64 family protein -
MR176_RS07585 1613685..1614080 - 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 -
MR176_RS07590 1614080..1614334 - 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 -
MR176_RS07595 1614427..1615374 - 948 WP_003403232.1 DUF732 domain-containing protein -
MR176_RS07600 1615478..1616542 - 1065 WP_003898532.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14376.37 Da        Isoelectric Point: 4.3568

>T295226 WP_003403246.1 NZ_OW052302:c1612462-1612055 [Mycobacterium tuberculosis]
VSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAAR
MWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV

Download         Length: 408 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9492.84 Da        Isoelectric Point: 11.9108

>AT295226 WP_003403244.1 NZ_OW052302:c1612719-1612459 [Mycobacterium tuberculosis]
MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTE
DLGPIR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3DBO

Antitoxin

Source ID Structure
PDB 3DBO
AlphaFold DB A0A7U4BSE4

References