Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 1574438..1575230 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag MR176_RS07375 Protein ID WP_003403386.1
Coordinates 1574438..1574875 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag MR176_RS07380 Protein ID WP_003403381.1
Coordinates 1574985..1575230 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS07350 1570901..1571074 - 174 WP_003898549.1 hypothetical protein -
MR176_RS07355 1571071..1571409 - 339 WP_003403405.1 PIN domain-containing protein -
MR176_RS07360 1571321..1571647 - 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR176_RS07365 1571710..1574073 - 2364 WP_003403397.1 arylsulfatase AtsD -
MR176_RS07370 1574187..1574441 + 255 WP_003911263.1 antitoxin VapB7 -
MR176_RS07375 1574438..1574875 + 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS07380 1574985..1575230 + 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
MR176_RS07385 1575217..1575525 + 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MR176_RS07390 1575801..1576517 + 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
MR176_RS07395 1576593..1576748 + 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
MR176_RS07400 1576843..1577226 + 384 WP_015629650.1 hypothetical protein -
MR176_RS07405 1577614..1578624 - 1011 WP_003911248.1 ABC transporter ATP-binding protein -
MR176_RS07410 1578705..1580211 - 1507 Protein_1464 carotenoid cleavage oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T295223 WP_003403386.1 NZ_OW052302:1574438-1574875 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT295223 WP_003403381.1 NZ_OW052302:1574985-1575230 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References