Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1314241..1314860 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MR176_RS06050 Protein ID WP_003404726.1
Coordinates 1314241..1314675 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag MR176_RS06055 Protein ID WP_003898641.1
Coordinates 1314681..1314860 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS06025 1309576..1310814 + 1239 WP_003404744.1 acetyl-CoA acetyltransferase -
MR176_RS06030 1310816..1312324 + 1509 WP_003404742.1 carotenoid oxygenase family protein -
MR176_RS06035 1312491..1312721 + 231 WP_003898642.1 hypothetical protein -
MR176_RS06040 1312856..1313305 - 450 WP_003404738.1 hypothetical protein -
MR176_RS06045 1313370..1314143 - 774 WP_003404735.1 VOC family protein -
MR176_RS06050 1314241..1314675 - 435 WP_003404726.1 SRPBCC family protein Toxin
MR176_RS06055 1314681..1314860 - 180 WP_003898641.1 antitoxin Antitoxin
MR176_RS06060 1314986..1315144 - 159 WP_003404720.1 hypothetical protein -
MR176_RS06065 1315417..1317810 - 2394 WP_016719446.1 cation-translocating P-type ATPase -
MR176_RS06070 1317807..1319387 - 1581 WP_003909313.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T295221 WP_003404726.1 NZ_OW052302:c1314675-1314241 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT295221 WP_003898641.1 NZ_OW052302:c1314860-1314681 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References