Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1304357..1305330 | Replicon | chromosome |
| Accession | NZ_OW052302 | ||
| Organism | Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | O05911 |
| Locus tag | MR176_RS05995 | Protein ID | WP_003404756.1 |
| Coordinates | 1304357..1304857 (-) | Length | 167 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | G0TFR4 |
| Locus tag | MR176_RS06000 | Protein ID | WP_003404754.1 |
| Coordinates | 1304854..1305330 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MR176_RS05975 | 1300204..1301856 | - | 1653 | WP_003404761.1 | IS607 family element RNA-guided endonuclease TnpB | - |
| MR176_RS05980 | 1301856..1302437 | - | 582 | WP_003404760.1 | IS607-like element IS1535 family transposase | - |
| MR176_RS05985 | 1302725..1304044 | + | 1320 | WP_015629751.1 | IS256-like element IS1554 family transposase | - |
| MR176_RS05995 | 1304357..1304857 | - | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
| MR176_RS06000 | 1304854..1305330 | - | 477 | WP_003404754.1 | DUF1778 domain-containing protein | Antitoxin |
| MR176_RS06005 | 1305419..1305673 | - | 255 | WP_015629749.1 | hypothetical protein | - |
| MR176_RS06010 | 1305673..1307454 | - | 1782 | WP_003404749.1 | BCCT family transporter | - |
| MR176_RS06015 | 1307898..1308197 | + | 300 | WP_003404748.1 | PE family protein | - |
| MR176_RS06020 | 1308212..1309483 | + | 1272 | WP_003404747.1 | PPE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1274533..1305676 | 31143 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T295220 WP_003404756.1 NZ_OW052302:c1304857-1304357 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 17357.95 Da Isoelectric Point: 11.2467
>AT295220 WP_003404754.1 NZ_OW052302:c1305330-1304854 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | G0TFR4 |