Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1098014..1098645 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag MR176_RS04995 Protein ID WP_003405820.1
Coordinates 1098334..1098645 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag MR176_RS04990 Protein ID WP_003405836.1
Coordinates 1098014..1098334 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS04965 1093210..1093848 + 639 WP_003898730.1 lipid droplet-associated protein -
MR176_RS04970 1093845..1095092 + 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
MR176_RS04975 1095082..1095339 + 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
MR176_RS04980 1095349..1096461 + 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
MR176_RS04985 1096468..1098004 - 1537 Protein_989 carboxylesterase/lipase family protein -
MR176_RS04990 1098014..1098334 + 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
MR176_RS04995 1098334..1098645 + 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
MR176_RS05000 1098757..1099914 + 1158 WP_003898727.1 AI-2E family transporter -
MR176_RS05005 1099921..1100565 - 645 WP_003915494.1 DUF4245 domain-containing protein -
MR176_RS05010 1100621..1101709 + 1089 WP_003898726.1 class II fructose-bisphosphatase -
MR176_RS05015 1101740..1103164 + 1425 WP_003405805.1 class II fumarate hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T295218 WP_003405820.1 NZ_OW052302:1098334-1098645 [Mycobacterium tuberculosis]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT295218 WP_003405836.1 NZ_OW052302:1098014-1098334 [Mycobacterium tuberculosis]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References