Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 940143..940702 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag MR176_RS04260 Protein ID WP_003898789.1
Coordinates 940409..940702 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag MR176_RS04255 Protein ID WP_003406322.1
Coordinates 940143..940412 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS04245 935405..936193 + 789 WP_003406325.1 hypothetical protein -
MR176_RS04250 936335..940030 + 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
MR176_RS04255 940143..940412 + 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MR176_RS04260 940409..940702 + 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
MR176_RS04265 940759..941589 + 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
MR176_RS04270 941670..942530 - 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
MR176_RS04275 942710..944397 + 1688 Protein_846 PE family protein -
MR176_RS04280 944420..944851 - 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
MR176_RS04285 944848..945108 - 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T295215 WP_003898789.1 NZ_OW052302:940409-940702 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT295215 WP_003406322.1 NZ_OW052302:940143-940412 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References