Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 788378..789428 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag MR176_RS03595 Protein ID WP_003407164.1
Coordinates 788607..789428 (-) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag MR176_RS03590 Protein ID WP_003407167.1
Coordinates 788378..788614 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS03575 784348..785817 - 1470 WP_003900326.1 cytochrome b5 domain-containing protein -
MR176_RS03580 786013..786798 - 786 WP_003407180.1 lipoprotein LprF -
MR176_RS03585 787101..788306 + 1206 WP_003918234.1 serine hydrolase domain-containing protein -
MR176_RS03590 788378..788614 - 237 WP_003407167.1 hypothetical protein Antitoxin
MR176_RS03595 788607..789428 - 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
MR176_RS03600 789649..790035 + 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
MR176_RS03605 790174..792135 + 1962 WP_003407159.1 sigma-F factor regulator -
MR176_RS03610 792426..793211 + 786 WP_003407157.1 membrane protein -
MR176_RS03615 793208..793870 + 663 WP_003407152.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T295214 WP_003407164.1 NZ_OW052302:c789428-788607 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT295214 WP_003407167.1 NZ_OW052302:c788614-788378 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References