Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 754409..755064 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag MR176_RS03445 Protein ID WP_003898861.1
Coordinates 754663..755064 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag MR176_RS03440 Protein ID WP_003407272.1
Coordinates 754409..754666 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS03420 749596..751563 - 1968 WP_003407285.1 primosomal protein N' -
MR176_RS03425 751644..752381 - 738 WP_031647000.1 lysoplasmalogenase -
MR176_RS03430 752380..753342 + 963 WP_003407279.1 alpha/beta hydrolase -
MR176_RS03435 753367..754326 + 960 WP_003407276.1 alpha/beta hydrolase -
MR176_RS03440 754409..754666 + 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
MR176_RS03445 754663..755064 + 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS03450 755319..757049 + 1731 WP_031651139.1 PE family protein -
MR176_RS03455 757095..758129 - 1035 WP_003407264.1 AraC family transcriptional regulator -
MR176_RS03460 758207..759592 + 1386 WP_003407260.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T295213 WP_003898861.1 NZ_OW052302:754663-755064 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT295213 WP_003407272.1 NZ_OW052302:754409-754666 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References