Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 641766..642382 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag MR176_RS02945 Protein ID WP_003407593.1
Coordinates 641766..642083 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag MR176_RS02950 Protein ID WP_003900349.1
Coordinates 642080..642382 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS02915 636775..637803 - 1029 WP_003407612.1 glycosyltransferase family 2 protein -
MR176_RS02920 637848..638246 - 399 WP_003900351.1 hypothetical protein -
MR176_RS02925 638307..638519 + 213 WP_003898900.1 dodecin family protein -
MR176_RS02930 638640..639350 + 711 WP_235639255.1 class I SAM-dependent methyltransferase -
MR176_RS02935 639423..640712 - 1290 WP_003407599.1 serine hydrolase domain-containing protein -
MR176_RS02940 640765..641769 - 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
MR176_RS02945 641766..642083 - 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
MR176_RS02950 642080..642382 - 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
MR176_RS02955 642396..644648 - 2253 WP_003407587.1 methylmalonyl-CoA mutase -
MR176_RS02960 644649..646496 - 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T295212 WP_003407593.1 NZ_OW052302:c642083-641766 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT295212 WP_003900349.1 NZ_OW052302:c642382-642080 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References