Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 562700..563313 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag MR176_RS02595 Protein ID WP_003407786.1
Coordinates 562700..563104 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag MR176_RS02600 Protein ID WP_009935474.1
Coordinates 563110..563313 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS02585 558651..560948 + 2298 WP_003407790.1 malto-oligosyltrehalose synthase -
MR176_RS02590 560941..562683 + 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
MR176_RS02595 562700..563104 - 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
MR176_RS02600 563110..563313 - 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR176_RS02605 563366..564655 - 1290 WP_016719220.1 threonine ammonia-lyase -
MR176_RS02610 564690..565136 - 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
MR176_RS02615 565146..566294 - 1149 Protein_521 MMPL family transporter -
MR176_RS02620 566478..567086 - 609 WP_003407773.1 TetR/AcrR family transcriptional regulator -
MR176_RS02625 567154..567531 - 378 WP_003407771.1 fumarate reductase subunit FrdD -
MR176_RS02630 567528..567908 - 381 WP_031651142.1 fumarate reductase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T295211 WP_003407786.1 NZ_OW052302:c563104-562700 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT295211 WP_009935474.1 NZ_OW052302:c563313-563110 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References