Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 380387..381000 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag MR176_RS01775 Protein ID WP_003408465.1
Coordinates 380611..381000 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag MR176_RS01770 Protein ID WP_003408469.1
Coordinates 380387..380614 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS01750 376279..376989 + 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -
MR176_RS01755 376979..377398 + 420 WP_003408483.1 hypothetical protein -
MR176_RS01760 377441..378688 - 1248 WP_003408476.1 serine hydrolase -
MR176_RS01765 378685..380169 - 1485 WP_003408473.1 biotin carboxylase -
MR176_RS01770 380387..380614 + 228 WP_003408469.1 antitoxin Antitoxin
MR176_RS01775 380611..381000 + 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS01780 381048..381179 - 132 Protein_356 IS3 family transposase -
MR176_RS01790 381610..382389 - 780 WP_003408460.1 IclR family transcriptional regulator -
MR176_RS01795 382403..383221 - 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
MR176_RS01800 383274..383624 - 351 WP_003898986.1 cupin domain-containing protein -
MR176_RS01805 383624..384454 - 831 WP_003408448.1 cyclase family protein -
MR176_RS01810 384457..385371 - 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T295210 WP_003408465.1 NZ_OW052302:380611-381000 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT295210 WP_003408469.1 NZ_OW052302:380387-380614 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References