Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 359881..360341 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag MR176_RS01665 Protein ID WP_003898996.1
Coordinates 359881..360129 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag MR176_RS01670 Protein ID WP_003408528.1
Coordinates 360129..360341 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS01645 356055..356666 + 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -
MR176_RS01650 356656..357057 + 402 WP_003408538.1 hypothetical protein -
MR176_RS01655 357342..359042 - 1701 WP_003898998.1 serine/threonine protein kinase PknE -
MR176_RS01660 359136..359873 - 738 WP_003898997.1 hypothetical protein -
MR176_RS01665 359881..360129 - 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
MR176_RS01670 360129..360341 - 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR176_RS01675 360409..362091 + 1683 WP_003898994.1 SulP family inorganic anion transporter -
MR176_RS01680 362105..362389 - 285 WP_003408522.1 DUF1876 domain-containing protein -
MR176_RS01685 362676..363863 + 1188 WP_003898992.1 nitrate transporter NarK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T295209 WP_003898996.1 NZ_OW052302:c360129-359881 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT295209 WP_003408528.1 NZ_OW052302:c360341-360129 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References