Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 127975..128678 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag MR176_RS00655 Protein ID WP_003409778.1
Coordinates 128349..128678 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag MR176_RS00650 Protein ID WP_003409780.1
Coordinates 127975..128352 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS00610 123133..123324 + 192 WP_003409876.1 hypothetical protein -
MR176_RS00615 123345..124247 + 903 WP_003899097.1 hypothetical protein -
MR176_RS00620 124258..124608 + 351 WP_003409871.1 hypothetical protein -
MR176_RS00625 124722..124904 + 183 WP_003409870.1 hypothetical protein -
MR176_RS00630 124897..125298 - 402 WP_003409869.1 hypothetical protein -
MR176_RS00635 125362..125814 + 453 WP_003899095.1 lipoprotein -
MR176_RS00640 125969..127333 - 1365 WP_003903691.1 HNH endonuclease signature motif containing protein -
MR176_RS00645 127388..127978 + 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
MR176_RS00650 127975..128352 + 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
MR176_RS00655 128349..128678 + 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MR176_RS00660 128888..129658 - 771 WP_003409775.1 SDR family oxidoreductase -
MR176_RS00665 129655..130716 - 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MR176_RS00670 130713..131228 - 516 WP_003409718.1 flavin reductase family protein -
MR176_RS00675 131225..132295 - 1071 WP_003899091.1 epoxide hydrolase EphB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T295208 WP_003409778.1 NZ_OW052302:128349-128678 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT295208 WP_003409780.1 NZ_OW052302:127975-128352 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References