Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/ParE-RHH |
Location | 119097..119641 | Replicon | chromosome |
Accession | NZ_OW052302 | ||
Organism | Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis |
Toxin (Protein)
Gene name | parE | Uniprot ID | G0TLU9 |
Locus tag | MR176_RS00565 | Protein ID | WP_003409896.1 |
Coordinates | 119345..119641 (+) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | P67299 |
Locus tag | MR176_RS00560 | Protein ID | WP_003409899.1 |
Coordinates | 119097..119348 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MR176_RS00535 | 114824..115621 | - | 798 | WP_003899101.1 | ABC transporter permease | - |
MR176_RS00540 | 116520..117740 | + | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
MR176_RS00545 | 117773..118045 | + | 273 | WP_031651155.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
MR176_RS00550 | 118049..118456 | + | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
MR176_RS00555 | 118616..119110 | - | 495 | WP_003899099.1 | hypothetical protein | - |
MR176_RS00560 | 119097..119348 | + | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
MR176_RS00565 | 119345..119641 | + | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
MR176_RS00570 | 119690..120304 | + | 615 | WP_003901296.1 | hypothetical protein | - |
MR176_RS00575 | 120193..120738 | - | 546 | WP_003409891.1 | SecB-like chaperone | - |
MR176_RS00580 | 120735..121184 | - | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | - |
MR176_RS00585 | 121226..121603 | - | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | - |
MR176_RS00590 | 121578..122099 | + | 522 | WP_003904745.1 | hypothetical protein | - |
MR176_RS00595 | 122073..122384 | - | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
MR176_RS00600 | 122381..122596 | - | 216 | WP_003409878.1 | antitoxin | - |
MR176_RS00605 | 122836..123132 | + | 297 | WP_003409877.1 | hypothetical protein | - |
MR176_RS00610 | 123133..123324 | + | 192 | WP_003409876.1 | hypothetical protein | - |
MR176_RS00615 | 123345..124247 | + | 903 | WP_003899097.1 | hypothetical protein | - |
MR176_RS00620 | 124258..124608 | + | 351 | WP_003409871.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11268.64 Da Isoelectric Point: 6.8604
>T295206 WP_003409896.1 NZ_OW052302:119345-119641 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL
Download Length: 297 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TLU9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BUZ2 |