Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 85197..86095 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MR176_RS00370 Protein ID WP_003410001.1
Coordinates 85535..86095 (+) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MR176_RS00365 Protein ID WP_003410003.1
Coordinates 85197..85538 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS00330 80913..81269 + 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
MR176_RS00335 81322..81594 + 273 WP_003410017.1 DUF1490 family protein -
MR176_RS00340 81591..83843 + 2253 WP_016719189.1 cation transporter ATPase CptG -
MR176_RS00345 83943..84191 + 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MR176_RS00350 84185..84529 + 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MR176_RS00355 84618..84953 + 336 WP_003410009.1 dehydrogenase -
MR176_RS00360 84854..85111 - 258 WP_003410006.1 hypothetical protein -
MR176_RS00365 85197..85538 + 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MR176_RS00370 85535..86095 + 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MR176_RS00375 86615..87154 - 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MR176_RS00380 87380..87808 - 429 WP_003409992.1 cellulose-binding protein -
MR176_RS00385 88224..88823 - 600 WP_003409989.1 L-lysine exporter -
MR176_RS00390 88932..89843 + 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
MR176_RS00395 89928..90158 - 231 WP_003409980.1 DUF167 domain-containing protein -
MR176_RS00400 90273..90926 + 654 WP_003409976.1 cutinase Cfp21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T295204 WP_003410001.1 NZ_OW052302:85535-86095 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT295204 WP_003410003.1 NZ_OW052302:85197-85538 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References