Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 60226..60852 Replicon chromosome
Accession NZ_OW052302
Organism Mycobacterium tuberculosis strain Lineage 3.1.1 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag MR176_RS00245 Protein ID WP_003410075.1
Coordinates 60226..60624 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag MR176_RS00250 Protein ID WP_003911750.1
Coordinates 60625..60852 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR176_RS00215 55825..57081 + 1257 WP_016720149.1 HNH endonuclease signature motif containing protein -
MR176_RS00220 57209..57799 - 591 WP_003899131.1 IS110 family transposase -
MR176_RS00225 57753..58373 - 621 WP_003410086.1 IS110 family transposase -
MR176_RS00230 58461..58640 + 180 Protein_45 hypothetical protein -
MR176_RS00235 59077..59511 - 435 WP_003914358.1 DUF1398 domain-containing protein -
MR176_RS00240 59612..60043 + 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
MR176_RS00245 60226..60624 - 399 WP_003410075.1 PIN domain nuclease Toxin
MR176_RS00250 60625..60852 - 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR176_RS00255 61111..62280 + 1170 WP_003899126.1 ATP-binding protein -
MR176_RS00260 62469..62813 + 345 WP_003410065.1 ferredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T295202 WP_003410075.1 NZ_OW052302:c60624-60226 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT295202 WP_003911750.1 NZ_OW052302:c60852-60625 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References