Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 4208650..4209345 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MR259_RS19650 Protein ID WP_003905754.1
Coordinates 4208650..4209084 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag MR259_RS19655 Protein ID WP_003410814.1
Coordinates 4209091..4209345 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS19640 4204804..4207845 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
MR259_RS19645 4207838..4208671 + 834 WP_003899172.1 SWIM zinc finger family protein -
MR259_RS19650 4208650..4209084 - 435 WP_003905754.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS19655 4209091..4209345 - 255 WP_003410814.1 antitoxin Antitoxin
MR259_RS19660 4209361..4209618 - 258 WP_003410816.1 hypothetical protein -
MR259_RS19665 4210152..4211413 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
MR259_RS19670 4211923..4212219 + 297 WP_003410820.1 PE family protein -
MR259_RS19675 4212275..4213006 + 732 WP_003900467.1 PPE family protein -
MR259_RS19680 4213546..4214292 - 747 WP_003901330.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15632.05 Da        Isoelectric Point: 7.4681

>T295199 WP_003905754.1 NZ_OW052189:c4209084-4208650 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT295199 WP_003410814.1 NZ_OW052189:c4209345-4209091 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References