Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 4165317..4165953 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P0CL62
Locus tag MR259_RS19455 Protein ID WP_003410654.1
Coordinates 4165543..4165953 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P9WJ84
Locus tag MR259_RS19450 Protein ID WP_003410651.1
Coordinates 4165317..4165550 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS19435 4160765..4161166 + 402 WP_234796110.1 metal ABC transporter permease -
MR259_RS19440 4161167..4161571 - 405 WP_003410645.1 PPOX class F420-dependent oxidoreductase -
MR259_RS19445 4161655..4165239 - 3585 WP_003910889.1 cobaltochelatase subunit CobN -
MR259_RS19450 4165317..4165550 + 234 WP_003410651.1 type II toxin-antitoxin system antitoxin MazE7 Antitoxin
MR259_RS19455 4165543..4165953 + 411 WP_003410654.1 type II toxin-antitoxin system toxin endoribonuclease MazF7 Toxin
MR259_RS19460 4165937..4167028 + 1092 WP_003900454.1 precorrin-3B synthase -
MR259_RS19465 4167038..4167664 + 627 WP_031716373.1 precorrin-8X methylmutase -
MR259_RS19470 4167661..4169187 + 1527 WP_003410659.1 precorrin-2 C(20)-methyltransferase -
MR259_RS19475 4169133..4170356 - 1224 WP_003901321.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14235.42 Da        Isoelectric Point: 10.6228

>T295198 WP_003410654.1 NZ_OW052189:4165543-4165953 [Mycobacterium tuberculosis]
MAEPRRGDLWLVSLGAARAGEPGKHRPAVVVSVDELLTGIDDELVVVVPVSSSRSRTPLRPPVAPSEGVAADSVAVCRGV
RAVARARLVERLGALKPATMRAIENALTLILGLPTGPERGEAATHSPVRWTGGRDP

Download         Length: 411 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8450.25 Da        Isoelectric Point: 4.7954

>AT295198 WP_003410651.1 NZ_OW052189:4165317-4165550 [Mycobacterium tuberculosis]
MSTSTTIRVSTQTRDRLAAQARERGISMSALLTELAAQAERQAIFRAEREASHAETTTQAVRDEDREWEGTVGDGLG

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7DU4
PDB 5WYG
PDB 6A6X

Antitoxin

Source ID Structure
PDB 7DU4
PDB 6A6X
AlphaFold DB A0A7U4BV50

References