Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 4096174..4096800 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag MR259_RS19155 Protein ID WP_003410075.1
Coordinates 4096402..4096800 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A806JLL8
Locus tag MR259_RS19150 Protein ID WP_003911750.1
Coordinates 4096174..4096401 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS19140 4094213..4094557 - 345 WP_003410065.1 ferredoxin family protein -
MR259_RS19145 4094746..4095915 - 1170 WP_003899126.1 ATP-binding protein -
MR259_RS19150 4096174..4096401 + 228 WP_003911750.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR259_RS19155 4096402..4096800 + 399 WP_003410075.1 PIN domain nuclease Toxin
MR259_RS19160 4096983..4097414 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
MR259_RS19165 4097515..4097949 + 435 WP_003914358.1 DUF1398 domain-containing protein -
MR259_RS19170 4098386..4098565 - 180 Protein_3787 hypothetical protein -
MR259_RS19175 4098653..4099273 + 621 WP_003410086.1 IS110 family transposase -
MR259_RS19180 4099227..4099817 + 591 WP_003899131.1 IS110 family transposase -
MR259_RS19185 4099945..4101201 - 1257 WP_003902247.1 HNH endonuclease signature motif containing protein -
MR259_RS19190 4101555..4101755 + 201 Protein_3791 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T295196 WP_003410075.1 NZ_OW052189:4096402-4096800 [Mycobacterium tuberculosis]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8346.16 Da        Isoelectric Point: 4.1621

>AT295196 WP_003911750.1 NZ_OW052189:4096174-4096401 [Mycobacterium tuberculosis]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSNDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure
AlphaFold DB A0A806JLL8

References