Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4072435..4073021 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag MR259_RS19050 Protein ID WP_003410010.1
Coordinates 4072435..4072779 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag MR259_RS19055 Protein ID WP_003410014.1
Coordinates 4072773..4073021 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS19015 4068141..4068740 + 600 WP_003910883.1 L-lysine exporter -
MR259_RS19020 4069156..4069584 + 429 WP_003409992.1 cellulose-binding protein -
MR259_RS19025 4069810..4070349 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MR259_RS19030 4070869..4071429 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
MR259_RS19035 4071426..4071767 - 342 WP_003410003.1 DUF2384 domain-containing protein -
MR259_RS19040 4071853..4072110 + 258 WP_003410006.1 hypothetical protein -
MR259_RS19045 4072011..4072346 - 336 WP_003410009.1 dehydrogenase -
MR259_RS19050 4072435..4072779 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
MR259_RS19055 4072773..4073021 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
MR259_RS19060 4073121..4075436 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MR259_RS19065 4075433..4075705 - 273 WP_003410017.1 DUF1490 family protein -
MR259_RS19070 4075758..4076114 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
MR259_RS19075 4076271..4077038 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T295195 WP_003410010.1 NZ_OW052189:c4072779-4072435 [Mycobacterium tuberculosis]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT295195 WP_003410014.1 NZ_OW052189:c4073021-4072773 [Mycobacterium tuberculosis]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
PDB 7WJ0
PDB 7WNR
AlphaFold DB A0A7U4FAW9

References