Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 4070869..4071767 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag MR259_RS19030 Protein ID WP_003410001.1
Coordinates 4070869..4071429 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag MR259_RS19035 Protein ID WP_003410003.1
Coordinates 4071426..4071767 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS19000 4066038..4066691 - 654 WP_003409976.1 cutinase Cfp21 -
MR259_RS19005 4066806..4067036 + 231 WP_003409980.1 DUF167 domain-containing protein -
MR259_RS19010 4067121..4068032 - 912 WP_031716369.1 ArgP/LysG family DNA-binding transcriptional regulator -
MR259_RS19015 4068141..4068740 + 600 WP_003910883.1 L-lysine exporter -
MR259_RS19020 4069156..4069584 + 429 WP_003409992.1 cellulose-binding protein -
MR259_RS19025 4069810..4070349 + 540 WP_003900446.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37) -
MR259_RS19030 4070869..4071429 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
MR259_RS19035 4071426..4071767 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
MR259_RS19040 4071853..4072110 + 258 WP_003410006.1 hypothetical protein -
MR259_RS19045 4072011..4072346 - 336 WP_003410009.1 dehydrogenase -
MR259_RS19050 4072435..4072779 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
MR259_RS19055 4072773..4073021 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
MR259_RS19060 4073121..4075436 - 2316 WP_003899120.1 cation transporter ATPase CptG -
MR259_RS19065 4075433..4075705 - 273 WP_003410017.1 DUF1490 family protein -
MR259_RS19070 4075758..4076114 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T295194 WP_003410001.1 NZ_OW052189:c4071429-4070869 [Mycobacterium tuberculosis]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT295194 WP_003410003.1 NZ_OW052189:c4071767-4071426 [Mycobacterium tuberculosis]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References