Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4063543..4064231 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag MR259_RS18985 Protein ID WP_003409958.1
Coordinates 4063543..4063962 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag MR259_RS18990 Protein ID WP_003409968.1
Coordinates 4063971..4064231 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS18965 4059038..4059886 + 849 WP_003901306.1 class I SAM-dependent methyltransferase -
MR259_RS18970 4059849..4061294 - 1446 WP_003899115.1 APC family permease -
MR259_RS18975 4061473..4062159 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
MR259_RS18980 4062350..4063318 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
MR259_RS18985 4063543..4063962 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS18990 4063971..4064231 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MR259_RS18995 4064374..4066050 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
MR259_RS19000 4066038..4066691 - 654 WP_003409976.1 cutinase Cfp21 -
MR259_RS19005 4066806..4067036 + 231 WP_003409980.1 DUF167 domain-containing protein -
MR259_RS19010 4067121..4068032 - 912 WP_031716369.1 ArgP/LysG family DNA-binding transcriptional regulator -
MR259_RS19015 4068141..4068740 + 600 WP_003910883.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T295193 WP_003409958.1 NZ_OW052189:c4063962-4063543 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT295193 WP_003409968.1 NZ_OW052189:c4064231-4063971 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References