Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4028278..4028981 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag MR259_RS18745 Protein ID WP_003409778.1
Coordinates 4028278..4028607 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag MR259_RS18750 Protein ID WP_003409780.1
Coordinates 4028604..4028981 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS18725 4024661..4025731 + 1071 WP_003902252.1 epoxide hydrolase EphB -
MR259_RS18730 4025728..4026243 + 516 WP_003409718.1 flavin reductase family protein -
MR259_RS18735 4026240..4027301 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
MR259_RS18740 4027298..4028068 + 771 WP_003409775.1 SDR family oxidoreductase -
MR259_RS18745 4028278..4028607 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MR259_RS18750 4028604..4028981 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
MR259_RS18755 4028978..4029568 - 591 WP_003409784.1 SEC-C metal-binding domain-containing protein -
MR259_RS18760 4029623..4030987 + 1365 WP_003903691.1 HNH endonuclease signature motif containing protein -
MR259_RS18765 4031142..4031594 - 453 WP_003899095.1 lipoprotein -
MR259_RS18770 4031658..4032059 + 402 WP_003409869.1 hypothetical protein -
MR259_RS18775 4032052..4032234 - 183 WP_003409870.1 hypothetical protein -
MR259_RS18780 4032348..4032698 - 351 WP_003409871.1 hypothetical protein -
MR259_RS18785 4032709..4033611 - 903 WP_003899097.1 hypothetical protein -
MR259_RS18790 4033632..4033823 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T295190 WP_003409778.1 NZ_OW052189:c4028607-4028278 [Mycobacterium tuberculosis]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT295190 WP_003409780.1 NZ_OW052189:c4028981-4028604 [Mycobacterium tuberculosis]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References