Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3788396..3789009 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag MR259_RS17660 Protein ID WP_003408465.1
Coordinates 3788396..3788785 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag MR259_RS17665 Protein ID WP_003408469.1
Coordinates 3788782..3789009 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS17625 3784025..3784939 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
MR259_RS17630 3784942..3785772 + 831 WP_003408448.1 cyclase family protein -
MR259_RS17635 3785772..3786122 + 351 WP_003898986.1 cupin domain-containing protein -
MR259_RS17640 3786175..3786993 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
MR259_RS17645 3787007..3787786 + 780 WP_003408460.1 IclR family transcriptional regulator -
MR259_RS17655 3788217..3788348 + 132 Protein_3483 IS3 family transposase -
MR259_RS17660 3788396..3788785 - 390 WP_003408465.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS17665 3788782..3789009 - 228 WP_003408469.1 antitoxin Antitoxin
MR259_RS17670 3789227..3790711 + 1485 WP_003408473.1 biotin carboxylase -
MR259_RS17675 3790708..3791955 + 1248 WP_003408476.1 serine hydrolase -
MR259_RS17680 3791998..3792417 - 420 WP_003408483.1 hypothetical protein -
MR259_RS17685 3792407..3793117 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T295188 WP_003408465.1 NZ_OW052189:c3788785-3788396 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT295188 WP_003408469.1 NZ_OW052189:c3789009-3788782 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References