Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3422882..3423537 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag MR259_RS16060 Protein ID WP_003898861.1
Coordinates 3422882..3423283 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag MR259_RS16065 Protein ID WP_003407272.1
Coordinates 3423280..3423537 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS16045 3418354..3419739 - 1386 WP_003407260.1 cytochrome P450 -
MR259_RS16050 3419817..3420851 + 1035 WP_003407264.1 AraC family transcriptional regulator -
MR259_RS16055 3420897..3422627 - 1731 WP_009940170.1 PE family protein -
MR259_RS16060 3422882..3423283 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS16065 3423280..3423537 - 258 WP_003407272.1 CopG family transcriptional regulator Antitoxin
MR259_RS16070 3423620..3424579 - 960 WP_003407276.1 alpha/beta hydrolase -
MR259_RS16075 3424604..3425566 - 963 WP_003905554.1 alpha/beta hydrolase -
MR259_RS16080 3425565..3426302 + 738 WP_031647000.1 lysoplasmalogenase -
MR259_RS16085 3426383..3428350 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T295185 WP_003898861.1 NZ_OW052189:c3423283-3422882 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT295185 WP_003407272.1 NZ_OW052189:c3423537-3423280 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References