Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 3387159..3388209 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag MR259_RS15900 Protein ID WP_003407164.1
Coordinates 3387159..3387980 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag MR259_RS15905 Protein ID WP_003407167.1
Coordinates 3387973..3388209 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS15880 3382717..3383379 - 663 WP_003407152.1 membrane protein -
MR259_RS15885 3383376..3384161 - 786 WP_003407157.1 membrane protein -
MR259_RS15890 3384452..3386413 - 1962 WP_003407159.1 sigma-F factor regulator -
MR259_RS15895 3386552..3386938 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
MR259_RS15900 3387159..3387980 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
MR259_RS15905 3387973..3388209 + 237 WP_003407167.1 hypothetical protein Antitoxin
MR259_RS15910 3388281..3389486 - 1206 WP_003918234.1 serine hydrolase domain-containing protein -
MR259_RS15915 3389789..3390574 + 786 WP_003902048.1 lipoprotein LprF -
MR259_RS15920 3390770..3391384 + 615 Protein_3138 cytochrome b5-like heme/steroid binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T295184 WP_003407164.1 NZ_OW052189:3387159-3387980 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT295184 WP_003407167.1 NZ_OW052189:3387973-3388209 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References