Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3230206..3230894 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag MR259_RS15215 Protein ID WP_003406304.1
Coordinates 3230463..3230894 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag MR259_RS15210 Protein ID WP_003406302.1
Coordinates 3230206..3230466 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS15190 3225783..3226607 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
MR259_RS15195 3226612..3227793 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
MR259_RS15200 3227870..3228970 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
MR259_RS15205 3229141..3230130 + 990 WP_003406301.1 malate dehydrogenase -
MR259_RS15210 3230206..3230466 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
MR259_RS15215 3230463..3230894 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS15220 3230917..3232500 - 1584 WP_009940130.1 PE family protein -
MR259_RS15225 3232680..3233540 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
MR259_RS15230 3233621..3234451 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
MR259_RS15235 3234508..3234801 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
MR259_RS15240 3234798..3235067 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T295182 WP_003406304.1 NZ_OW052189:3230463-3230894 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT295182 WP_003406302.1 NZ_OW052189:3230206-3230466 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References