Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2868606..2869579 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag MR259_RS13470 Protein ID WP_003404756.1
Coordinates 2869079..2869579 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID G0TFR4
Locus tag MR259_RS13465 Protein ID WP_003404754.1
Coordinates 2868606..2869082 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS13445 2864453..2865724 - 1272 WP_003404747.1 PPE family protein -
MR259_RS13450 2865739..2866038 - 300 WP_003404748.1 PE family protein -
MR259_RS13455 2866482..2868263 + 1782 WP_003404749.1 BCCT family transporter -
MR259_RS13460 2868263..2868517 + 255 WP_003898646.1 hypothetical protein -
MR259_RS13465 2868606..2869082 + 477 WP_003404754.1 DUF1778 domain-containing protein Antitoxin
MR259_RS13470 2869079..2869579 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
MR259_RS13480 2869892..2871211 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
MR259_RS13485 2871499..2872080 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
MR259_RS13490 2872080..2873732 + 1653 WP_003905412.1 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T295179 WP_003404756.1 NZ_OW052189:2869079-2869579 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17357.95 Da        Isoelectric Point: 11.2467

>AT295179 WP_003404754.1 NZ_OW052189:2868606-2869082 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB G0TFR4

References