Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 2859076..2859695 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MR259_RS13415 Protein ID WP_003404726.1
Coordinates 2859261..2859695 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag MR259_RS13410 Protein ID WP_003898641.1
Coordinates 2859076..2859255 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS13395 2854549..2856129 + 1581 WP_003910977.1 serine hydrolase -
MR259_RS13400 2856126..2858519 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
MR259_RS13405 2858792..2858950 + 159 WP_003404720.1 hypothetical protein -
MR259_RS13410 2859076..2859255 + 180 WP_003898641.1 antitoxin Antitoxin
MR259_RS13415 2859261..2859695 + 435 WP_003404726.1 SRPBCC family protein Toxin
MR259_RS13420 2859793..2860566 + 774 WP_003404735.1 VOC family protein -
MR259_RS13425 2860631..2861080 + 450 WP_003404738.1 hypothetical protein -
MR259_RS13430 2861215..2861445 - 231 WP_003898642.1 hypothetical protein -
MR259_RS13435 2861612..2863120 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
MR259_RS13440 2863122..2864360 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T295178 WP_003404726.1 NZ_OW052189:2859261-2859695 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT295178 WP_003898641.1 NZ_OW052189:2859076-2859255 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References