Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2685619..2686328 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag MR259_RS12570 Protein ID WP_003403837.1
Coordinates 2685900..2686328 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag MR259_RS12565 Protein ID WP_003403834.1
Coordinates 2685619..2685876 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS12560 2683255..2685528 + 2274 WP_016330384.1 PE family protein -
MR259_RS12565 2685619..2685876 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
MR259_RS12570 2685900..2686328 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS12575 2686409..2686546 - 138 WP_003403839.1 hypothetical protein -
MR259_RS12585 2686705..2686950 + 246 WP_003403841.1 hypothetical protein -
MR259_RS12590 2687019..2687903 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
MR259_RS12595 2687914..2689086 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
MR259_RS12600 2689093..2690625 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T295177 WP_003403837.1 NZ_OW052189:2685900-2686328 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT295177 WP_003403834.1 NZ_OW052189:2685619-2685876 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References