295176

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2600026..2600714 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag MR259_RS12090 Protein ID WP_003403386.1
Coordinates 2600026..2600463 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O06777
Locus tag MR259_RS12095 Protein ID WP_003911263.1
Coordinates 2600460..2600714 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS12060 2596277..2597287 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
MR259_RS12065 2597675..2598058 - 384 WP_003403365.1 ribonuclease VapC6 -
MR259_RS12070 2598153..2598308 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
MR259_RS12075 2598384..2599100 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
MR259_RS12080 2599376..2599684 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
MR259_RS12085 2599671..2599916 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
MR259_RS12090 2600026..2600463 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
MR259_RS12095 2600460..2600714 - 255 WP_003911263.1 antitoxin VapB7 Antitoxin
MR259_RS12100 2600828..2603191 + 2364 WP_003901895.1 arylsulfatase AtsD -
MR259_RS12105 2603254..2603580 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR259_RS12110 2603492..2603830 + 339 WP_003403405.1 PIN domain-containing protein -
MR259_RS12115 2603827..2604000 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T295176 WP_003403386.1 NZ_OW052189:c2600463-2600026 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9450.99 Da        Isoelectric Point: 11.7073

>AT295176 WP_003911263.1 NZ_OW052189:c2600714-2600460 [Mycobacterium tuberculosis]
MSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALR
ARRG

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB A0A806JQG1

References