Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2599376..2599916 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name mazF Uniprot ID P9WII0
Locus tag MR259_RS12080 Protein ID WP_003403376.1
Coordinates 2599376..2599684 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag MR259_RS12085 Protein ID WP_003403381.1
Coordinates 2599671..2599916 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS12055 2594691..2596196 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
MR259_RS12060 2596277..2597287 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
MR259_RS12065 2597675..2598058 - 384 WP_003403365.1 ribonuclease VapC6 -
MR259_RS12070 2598153..2598308 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
MR259_RS12075 2598384..2599100 - 717 WP_003403371.1 CPBP family intramembrane metalloprotease -
MR259_RS12080 2599376..2599684 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MR259_RS12085 2599671..2599916 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
MR259_RS12090 2600026..2600463 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
MR259_RS12095 2600460..2600714 - 255 WP_003911263.1 antitoxin VapB7 -
MR259_RS12100 2600828..2603191 + 2364 WP_003901895.1 arylsulfatase AtsD -
MR259_RS12105 2603254..2603580 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR259_RS12110 2603492..2603830 + 339 WP_003403405.1 PIN domain-containing protein -
MR259_RS12115 2603827..2604000 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11320.10 Da        Isoelectric Point: 11.6554

>T295174 WP_003403376.1 NZ_OW052189:c2599684-2599376 [Mycobacterium tuberculosis]
MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRR
ITRLSPARLHEACQTLRASTGC

Download         Length: 309 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT295174 WP_003403381.1 NZ_OW052189:c2599916-2599671 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSE5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References