Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2560548..2561197 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID P67241
Locus tag MR259_RS11880 Protein ID WP_003403236.1
Coordinates 2560802..2561197 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ34
Locus tag MR259_RS11875 Protein ID WP_003403235.1
Coordinates 2560548..2560802 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS11850 2555674..2555757 + 84 Protein_2342 galactose-1-phosphate uridylyltransferase -
MR259_RS11855 2555776..2556857 + 1082 Protein_2343 galactose-1-phosphate uridylyltransferase -
MR259_RS11860 2556854..2557945 + 1092 WP_003900977.1 galactokinase -
MR259_RS11865 2558340..2559404 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MR259_RS11870 2559508..2560455 + 948 WP_003403232.1 DUF732 domain-containing protein -
MR259_RS11875 2560548..2560802 + 255 WP_003403235.1 type II toxin-antitoxin system antitoxin VapB30 Antitoxin
MR259_RS11880 2560802..2561197 + 396 WP_003403236.1 type II toxin-antitoxin system toxin ribonuclease C30 Toxin
MR259_RS11885 2561291..2562031 - 741 WP_003403239.1 TVP38/TMEM64 family protein -
MR259_RS11890 2562163..2562423 + 261 WP_003403244.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MR259_RS11895 2562420..2562827 + 408 WP_003403246.1 type II toxin-antitoxin system VapC family toxin -
MR259_RS11900 2562899..2564050 - 1152 WP_003403248.1 FIST N-terminal domain-containing protein -
MR259_RS11905 2564143..2565870 - 1728 WP_003901883.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14250.04 Da        Isoelectric Point: 4.7475

>T295171 WP_003403236.1 NZ_OW052189:2560802-2561197 [Mycobacterium tuberculosis]
MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAAR
AAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP

Download         Length: 396 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9139.52 Da        Isoelectric Point: 9.2702

>AT295171 WP_003403235.1 NZ_OW052189:2560548-2560802 [Mycobacterium tuberculosis]
MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDER
GLPA

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4XGR
PDB 4XGQ

Antitoxin

Source ID Structure
PDB 4XGR
PDB 4XGQ
AlphaFold DB A0A7U4BSC2

References