295170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2554920..2555545 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag MR259_RS11845 Protein ID WP_003403218.1
Coordinates 2555144..2555545 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag MR259_RS11840 Protein ID WP_003403213.1
Coordinates 2554920..2555147 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS11815 2550099..2550320 - 222 WP_242382540.1 DUF4926 domain-containing protein -
MR259_RS11820 2550462..2551067 + 606 WP_003898526.1 hypothetical protein -
MR259_RS11825 2551086..2553653 - 2568 WP_003901879.1 SEC-C metal-binding domain-containing protein -
MR259_RS11830 2553737..2554486 + 750 WP_003898528.1 hypothetical protein -
MR259_RS11835 2554483..2554725 + 243 WP_003403210.1 hypothetical protein -
MR259_RS11840 2554920..2555147 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
MR259_RS11845 2555144..2555545 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
MR259_RS11850 2555674..2555757 + 84 Protein_2342 galactose-1-phosphate uridylyltransferase -
MR259_RS11855 2555776..2556857 + 1082 Protein_2343 galactose-1-phosphate uridylyltransferase -
MR259_RS11860 2556854..2557945 + 1092 WP_003900977.1 galactokinase -
MR259_RS11865 2558340..2559404 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
MR259_RS11870 2559508..2560455 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T295170 WP_003403218.1 NZ_OW052189:2555144-2555545 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT295170 WP_003403213.1 NZ_OW052189:2554920-2555147 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References