Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 106025..107742 Replicon chromosome
Accession NC_021288
Organism Burkholderia sp. RPE64

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BRPE64_RS21185 Protein ID WP_016346896.1
Coordinates 106882..107742 (-) Length 287 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID R4WNQ5
Locus tag BRPE64_RS21180 Protein ID WP_016346895.1
Coordinates 106025..106885 (-) Length 287 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BRPE64_RS21160 101237..102727 - 1491 WP_016346891.1 aldehyde dehydrogenase -
BRPE64_RS21165 102742..103566 - 825 WP_016346892.1 aspartate dehydrogenase -
BRPE64_RS21170 103559..105226 - 1668 WP_016346893.1 thiamine pyrophosphate-binding protein -
BRPE64_RS21175 105219..106028 - 810 WP_016346894.1 SDR family oxidoreductase -
BRPE64_RS21180 106025..106885 - 861 WP_016346895.1 IclR family transcriptional regulator Antitoxin
BRPE64_RS21185 106882..107742 - 861 WP_016346896.1 alpha/beta fold hydrolase Toxin
BRPE64_RS21190 107752..108279 - 528 WP_016346897.1 cupin domain-containing protein -
BRPE64_RS21195 108310..109053 - 744 WP_016346898.1 SDR family oxidoreductase -
BRPE64_RS21200 109046..110107 - 1062 WP_016346899.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BRPE64_RS21205 110125..110433 - 309 WP_016346900.1 hypothetical protein -
BRPE64_RS21210 110435..110752 - 318 WP_016346901.1 non-heme iron oxygenase ferredoxin subunit -
BRPE64_RS21215 111194..112267 + 1074 WP_016346902.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(36-265)

Antitoxin

Transcription regulator IclR, N-terminal

(21-69)


Sequences

Toxin        


Download         Length: 287 a.a.        Molecular weight: 30058.38 Da        Isoelectric Point: 6.9607

>T29517 WP_016346896.1 NC_021288:c107742-106882 [Caballeronia insecticola]
MNIETLARFPDMQIDTTHGITGYREAGALHSRALPVVLLHGIGSGAASWVRQLDALGAKRRVLAWDAPGYGVSTPVRAAS
PVASDYANALRAWLDALDIARCVLVGHSLGAIIAGSFAAAMPERVAGLLLISPAAGYGAASKDVRESKRDARLKMLDELG
PQGLAQERSANMVSPFADDPARDWVRWNMARIVPAGYAQATHLLANADLATDIARFHGRMAVAVGAEDAITPPAACAPIA
QAAHVSLQVIPRAGHAGYVESPAAYTALIDSFCQGIECHMKDGVPQ

Download         Length: 861 bp

>T29517 NC_021288:c107742-106882 [Caballeronia insecticola]
ATGAACATCGAGACGCTCGCGCGTTTTCCGGACATGCAGATCGATACCACGCACGGCATCACGGGTTATCGCGAGGCGGG
TGCGCTGCACTCGCGTGCCCTGCCCGTCGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCGTCGTGGGTTCGGCAGCTCG
ACGCACTCGGCGCGAAGCGTCGCGTACTTGCGTGGGACGCGCCGGGTTATGGCGTATCGACGCCGGTCCGCGCTGCATCG
CCCGTCGCTTCCGACTATGCGAACGCACTGCGCGCGTGGCTCGATGCGCTGGATATCGCGCGCTGCGTGCTCGTCGGGCA
TTCGCTCGGCGCGATCATCGCGGGTTCGTTCGCGGCCGCCATGCCCGAGCGCGTCGCGGGCTTGTTGTTGATATCGCCCG
CTGCGGGTTACGGCGCTGCATCGAAGGACGTGCGCGAATCGAAGCGCGATGCACGCCTGAAGATGCTCGACGAACTCGGC
CCGCAAGGACTCGCGCAAGAGCGCAGCGCGAACATGGTGTCGCCATTCGCCGACGATCCCGCGCGCGACTGGGTTCGCTG
GAACATGGCGCGCATCGTGCCCGCAGGTTACGCGCAAGCGACGCATCTGCTGGCCAATGCCGATCTCGCCACGGACATCG
CGCGCTTTCACGGACGCATGGCCGTTGCAGTGGGCGCGGAAGACGCGATCACGCCGCCCGCCGCCTGTGCGCCCATCGCG
CAGGCCGCGCATGTCAGCCTGCAAGTGATCCCGCGTGCCGGACATGCGGGCTATGTCGAATCTCCCGCCGCCTATACGGC
GCTGATCGACTCGTTTTGCCAGGGCATCGAATGTCACATGAAAGACGGAGTACCGCAATGA

Antitoxin


Download         Length: 287 a.a.        Molecular weight: 31560.09 Da        Isoelectric Point: 6.5107

>AT29517 WP_016346895.1 NC_021288:c106885-106025 [Caballeronia insecticola]
MTSIATEEADKGEPTYIVPGLERGLKILTEFSPREPVLGAPELSRRLGIPRTTVFRLLQTLESLGFLERADKDRNYRLGV
AVLRLGFEYLSSLELTDLGLPVIEALRDATGLTSHILIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLPAHATTHGHVLM
GDLSLDELRALYPEAHLERFTKSTPETVEELYERVKEDAERGFATSQSSFERGISVVTAPVRNDTGRIVAVITTTIPRPE
IDAALLETGLIDRVREAADTLSMRLNYRPAARAATPSRYMKSLGLQ

Download         Length: 861 bp

>AT29517 NC_021288:c106885-106025 [Caballeronia insecticola]
ATGACATCCATCGCCACGGAAGAAGCCGACAAGGGCGAACCGACCTATATCGTGCCGGGACTCGAACGCGGCCTCAAGAT
TCTCACCGAGTTTTCGCCGCGCGAACCGGTGCTCGGCGCACCCGAATTGTCGCGGCGCCTGGGCATTCCGCGCACGACAG
TGTTCCGCTTGCTGCAGACGCTCGAATCGCTCGGCTTTCTGGAGCGCGCCGACAAGGACCGCAATTATCGGCTCGGCGTG
GCCGTGCTGCGCCTCGGCTTCGAATATCTGAGTTCGCTCGAACTCACCGATCTCGGCCTGCCGGTGATCGAAGCATTGCG
CGATGCGACCGGGCTCACGAGCCACATCCTGATCCGCGATGGCCGCGATGTCGTGTTCGTGGCCAAGGCGCAGAGTCACG
CGCCGATCTTCAGTTCGGTGAAGGTGAACGTCGGCACGCGACTGCCCGCGCATGCGACCACGCACGGTCACGTTCTGATG
GGCGATCTCTCGCTCGACGAACTGCGCGCGCTTTATCCCGAGGCGCATCTCGAACGCTTCACGAAGTCGACGCCGGAGAC
GGTCGAAGAACTGTACGAGCGCGTGAAAGAAGACGCCGAACGCGGCTTCGCGACGAGTCAATCGTCGTTCGAGCGCGGCA
TTTCCGTCGTCACCGCGCCGGTGCGCAACGACACGGGACGCATCGTCGCCGTCATCACGACGACGATTCCGCGTCCCGAG
ATCGACGCCGCGCTGCTCGAAACCGGGCTCATCGACCGCGTGCGCGAAGCCGCCGACACGCTCTCGATGCGTCTCAACTA
TCGTCCGGCCGCGCGTGCTGCCACGCCGAGCCGCTATATGAAGTCTCTGGGGTTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB R4WNQ5

References