Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-PHD
Location 2538977..2539623 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name vapC Uniprot ID O07783
Locus tag MR259_RS11725 Protein ID WP_003403122.1
Coordinates 2538977..2539369 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ86
Locus tag MR259_RS11730 Protein ID WP_003403125.1
Coordinates 2539366..2539623 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS11710 2534639..2536165 + 1527 WP_003403112.1 virulence factor Mce family protein -
MR259_RS11715 2536228..2537370 + 1143 WP_003911253.1 virulence factor Mce family protein -
MR259_RS11720 2537375..2538925 + 1551 WP_003905349.1 MCE family protein -
MR259_RS11725 2538977..2539369 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 Toxin
MR259_RS11730 2539366..2539623 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 Antitoxin
MR259_RS11735 2539806..2541041 - 1236 WP_003403128.1 ATP-binding protein -
MR259_RS11740 2541292..2541705 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin -
MR259_RS11745 2541702..2541938 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 -
MR259_RS11750 2542042..2542548 - 507 WP_003900973.1 two component system sensor kinase HK1 -
MR259_RS11755 2542662..2543192 - 531 WP_003917320.1 two component system sensor kinase HK2 -
MR259_RS11760 2543176..2543871 - 696 WP_003918099.1 two-component system response regulator TcrA -
MR259_RS11765 2543994..2544305 + 312 WP_003403164.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-122)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14080.08 Da        Isoelectric Point: 4.6558

>T295167 WP_003403122.1 NZ_OW052189:c2539369-2538977 [Mycobacterium tuberculosis]
VNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAW
ALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI

Download         Length: 393 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9681.06 Da        Isoelectric Point: 7.0175

>AT295167 WP_003403125.1 NZ_OW052189:c2539623-2539366 [Mycobacterium tuberculosis]
MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTT
DDVRW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F8V4

Antitoxin

Source ID Structure
AlphaFold DB G0TQ86

References