Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 2288308..2289319 Replicon chromosome
Accession NZ_OW052189
Organism Mycobacterium tuberculosis strain Lineage 2.2.7 isolate Mycobacterium tuberculosis

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MR259_RS10530 Protein ID WP_003401859.1
Coordinates 2288308..2288901 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MR259_RS10535 Protein ID WP_003401860.1
Coordinates 2288930..2289319 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MR259_RS10510 2283957..2285339 + 1383 WP_003898415.1 magnesium transporter -
MR259_RS10515 2285351..2286385 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MR259_RS10520 2286481..2287164 + 684 WP_003401857.1 VTT domain-containing protein -
MR259_RS10525 2287153..2288283 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
MR259_RS10530 2288308..2288901 - 594 WP_003401859.1 zeta toxin family protein Toxin
MR259_RS10535 2288930..2289319 - 390 WP_003401860.1 hypothetical protein Antitoxin
MR259_RS10540 2289400..2290611 - 1212 WP_003401861.1 VWA domain-containing protein -
MR259_RS10545 2290617..2291219 - 603 WP_003898417.1 SRPBCC family protein -
MR259_RS10550 2291233..2292129 - 897 WP_003898418.1 MoxR family ATPase -
MR259_RS10555 2292126..2292719 - 594 WP_003401864.1 NTP transferase domain-containing protein -
MR259_RS10560 2292716..2293471 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T295164 WP_003401859.1 NZ_OW052189:c2288901-2288308 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT295164 WP_003401860.1 NZ_OW052189:c2289319-2288930 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References